Cyclobutane derivatives, as molecular building blocks, has gained increasing importance. They can be used as starting materials for the synthesis of both acyclic and cyclic systems,including carbo- and heterobicyclic and oligocylic compounds[1].They aslo are witnessing significant prominence in medicinal chemistry discovery programs,and the various reports that have documented the benefits accompanying their use in discovery candidates are driving the increased visibility.The range of advantages includes structural novelty along with improved physicochemical and pharmaco-kinetic properties[2].More and more lead compounds containing cyclobutane skeletons have been designed, synthesized and separated[3-7].
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A series of medicinal products containing cyclobutane has been firmly incorporated
in medical practice.
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[1] Chemical Reviews (2003), 103(4), 1485-1537. [2] Chemical Reviews (2014), 114(16), 8257-8322. [3] European Journal of Medicinal Chemistry (2006), 41(2), 201-207. [4] European Journal of Medicinal Chemistry (2006), 41(5), 664-669. [5] Journal of Medicinal Chemistry (2012), 55(1), 250-267. [6] Journal of Medicinal Chemistry (2014), 57(4), 1252-1275. [7] Journal of Natural Products (2018), 81(2), 307-315.
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